Pharmacological inhibition of Ubiquitin-Specific Peptidase 10 (USP10) with spautin-1 attenuates adipogenesis through CCAAT/Enhancer-Binding Protein Beta (C/EBPβ) destabilization.

ABSTRACT: The pharmacological control of lipid accumulation in white adipose tissue (WAT) is a key area of focus in obesity research, yet the role of deubiquitination in adipocyte lipid storage remains underexplored. We found that spautin-1, an inhibitor of the deubiquitinases ubiquitin-specific peptidase 10 (USP10) and 13 (USP13), suppressed lipid accumulation during adipogenesis. Therefore, we investigated whether blocking deubiquitination restricts adipogenesis and acts as the underlying mechanism. Mining public datasets revealed that USP10 expression is substantially increased in the adipose tissue (AT) from individuals with obesity. Moreover, USP10 exhibited a depot-specific expression pattern, with higher levels in visceral AT than in subcutaneous AT, whereas no such difference was observed fo

SUBMITTER: Erdenebileg Z 

PROVIDER: S-EPMC12717316 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature