A Human Model of Oligodendrocyte Development Shows MCL-1 Influences Oligodendrocyte Morphogenesis.

ABSTRACT: Oligodendrocytes are the myelinating cells of the central nervous system. Regulation of the early stages of oligodendrocyte development is critical to the function of the cell. Specifically, myelin sheath formation is an energetically demanding event that requires precision, as alterations may lead to dysmyelination. Fatty acid β-oxidation has been shown to be critical for the function of oligodendrocytes. We previously showed that myeloid cell leukemia-1 (MCL-1), a well-characterized anti-apoptotic protein, is required for the development of murine oligodendrocytes in vivo. Further, MCL-1 regulates long-chain fatty acid β-oxidation in cancer cells through its interaction with Acyl-CoA synthetase long-chain family member 1 (ACSL1), an enzyme responsible for the conversion of free long-chai

SUBMITTER: Gil M 

PROVIDER: S-EPMC12717335 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature