RERE-AS1 as a regulator of immune modulation and therapeutic response in breast cancer.

ABSTRACT:

Background and aims

Breast cancer (BRCA) remains one of the most prevalent malignancies and a major threat to women's health worldwide. The biological role and mechanistic basis of the long non-coding RNA (lncRNA) RERE-AS1 in BRCA remain unclear.

Methods

Clinical and RNA sequencing data from BRCA patients were analyzed to determine RERE-AS1 expression levels. RNA fluorescence in situ hybridization (FISH) was used to visualize its distribution in tumor tissues. Functional assays were conducted in MCF-7 and T47D cells to assess the effects of RERE-AS1 on cellular proliferation, migration, invasion, and apoptosis using Cell Counting Kit-8 (CCK-8), Transwell assays, and flow cytometry. Cell cycle progression was also evaluated. A co-culture system of BRCA cells and immune cells

SUBMITTER: Jiang S 

PROVIDER: S-EPMC12717349 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature