Risk factors of early-onset type 2 diabetes: A systematic review and meta-analysis.

ABSTRACT: BackgroundEarly-onset type 2 diabetes (T2DM), diagnosed before age 40, progresses rapidly and has a higher risk of complications compared to late-onset T2DM. Its global prevalence is rising, but the underlying risk factors are insufficiently understood.ObjectiveThis systematic review and meta-analysis aimed to evaluate risk factors associated with early-onset T2DM to support clinical decision-making and inform preventive strategies.Methods37 studies (cohort, case-control, cross-sectional) were identified from PubMed, Web of Science, and Embase up to October 31, 2024. Data were analyzed using STATA 17.0, and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Subgroup analyses were performed by region, study type, and sample size.ResultsCompared with normoglycemic

SUBMITTER: Hu S 

PROVIDER: S-EPMC12717410 | biostudies-literature | 2025 Nov-Dec

REPOSITORIES: biostudies-literature