HHV-8-Associated Hemophagocytic Lymphohistiocytosis in a HIV-Negative and Nontransplant Man: A Case Report and Literature Review.

ABSTRACT: Hemophagocytic lymphohistiocytosis (HLH) is a critical and life-threatening syndrome, which can rapidly progress to mortality without immediate or targeted therapeutic intervention. Human herpesvirus 8 (HHV-8, or Kaposi sarcoma-associated herpesvirus (KSHV)) is a rarely described viral cause of secondary HLH, especially in immunocompetent adults. Here, we report an uncommon case of HLH after HHV-8 infection, with no history of transplantation or HIV infection. The pathophysiological mechanisms of secondary HLH remain incompletely understood. There might be potential overlapping pathogenic pathways between HHV-8-associated HLH and KICS pathogenesis. E3 ubiquitin ligases may be a critical factor in the pathogenesis of HHV-8-associated secondary HLH. Ferritin testing, peripheral blood smears,

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12717441 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature