Longitudinal brain morphometry in Parkinson's disease clinical subtypes: Distinct signatures forecast behavioral change within subtypes.

ABSTRACT:

Background

Parkinson's disease (PD) is clinically heterogenous. We previously identified a multi-domain classification of distinct PD subtypes in participants without dementia, yielding Motor Only, Psychiatric & Motor, and Cognitive & Motor subtypes. These PD subtypes may exhibit different rates of brain atrophy. We aim to determine baseline and longitudinal morphometric brain signatures of PD clinical subtypes and their relationship to behavioral change.

Methods

213 PD and 73 control participants completed T1-weighted structural MRIs and motor, cognitive, and psychiatric measures at baseline and every 1-3 years. We used FreeSurfer-v7.3 to obtain cortical thickness and brain volume measures, with manual edits as necessary. We used hierarchical linear models for longitudinal

SUBMITTER: Eid AM 

PROVIDER: S-EPMC12717520 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature