Exosomes derived from platelet-rich plasma promote hair regeneration by regulating the SIRT1/FoxO3a pathway to alleviate oxidative stress.

ABSTRACT:

Introduction

Alopecia is a common disorder that severely affects the mental well-being and quality of life of those affected, yet available treatment options remain limited. Emerging evidence suggests that exosomes from diverse cellular sources possess therapeutic potential for alopecia. However, research on the application of platelet-rich plasma-derived exosomes (PRP-exos) in promoting hair growth is still relatively sparse. This study aims to elucidate the effects of PRP-exos on hair growth and to investigate the associated molecular mechanisms.

Methods

We employed conventional molecular biology techniques to evaluate the impacts of PRP-exos on hair follicle stem cells (HFSCs) in terms of proliferation, apoptosis, and migration, as well as their protective effects against

SUBMITTER: Yang X 

PROVIDER: S-EPMC12717658 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature