Prognostic Value of UBE2S, HIF-1α, and FOXM1 Expression in Esophageal Squamous Cell Carcinoma.

ABSTRACT:

Objective

The present investigation was aimed to examine ubiquitin-conjugating enzyme E2S (UBE2S), hypoxia-inducible factor (HIF)-1α, and factor forkhead box M1 (FOXM1) levels in esophageal squamous cell carcinoma (ESCC) and esophageal low-grade intraepithelial neoplasia (LIN), high-grade intraepithelial neoplasia (HIN). Additionally, the investigation explored the correlation between these levels and clinicopathological features in addition to prognosis.

Methods

To investigate the expression patterns of UBE2S, HIF-1α, and FOXM1, immunohistochemical staining was performed on tissue samples, including LIN, HIN, ESCC, and healthy controls. Subsequently, the chi-square test was applied to analyze the correlations between the expression levels of the three proteins and the clini

SUBMITTER: Li W 

PROVIDER: S-EPMC12717677 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature