The role of placental DNA methylation in the pathogenesis of chronic intervillositis of unknown etiology.

ABSTRACT:

Objectives

Chronic intervillositis of unknown etiology (CIUE) is the pathological influx of maternal inflammatory cells into the intervillous space of the placenta without demonstrable cause. CIUE is associated with placental damage and increased risk of pregnancy loss, fetal demise, and growth restriction. The pathogenic mechanism is unclear, and we lack biomarkers for detection, and treatments to prevent recurrence. DNA methylation (DNAme) is a biomarker altered in association with many disease states. We hypothesized that CIUE may be associated with a distinct signature placental DNAme signature.

Methods

DNAme was profiled using the Illumina Infinium MethylationEPIC v2.0 array on fresh-frozen placental tissue. After quality control, data were available for 24 CIUE (14 hig

SUBMITTER: Inkster AM 

PROVIDER: S-EPMC12717689 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature