Culture conditions impact the protein expression profile of Mycobacterium bovis BCG strains Moreau and Pasteur.

ABSTRACT:

Background

The Bacille Calmette-Guérin (BCG) vaccine, developed in the early 20th century, remains the only widely approved prophylactic against tuberculosis (TB). It was derived from an attenuated strain of Mycobacterium bovis. Its protective efficacy against pulmonary TB in adolescents and adults varies from 0 to 80%; genetic differences among worldwide vaccine strains contribute to this variation. The Brazilian vaccine strain used until 2017, BCG Moreau, is considered a primitive strain and more immunogenic, closer to the original BCG when compared to newer strains, such as BCG Pasteur. The characterization of BCG daughter-strains can contribute not only to a better understanding of the vaccine and its protective effect, but also to elucidating how different BCG culture conditio

SUBMITTER: Correa PR 

PROVIDER: S-EPMC12717700 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature