Construction and verification of a prognostic model for prostate cancer based on ribosome biogenesis-related genes.

ABSTRACT:

Background

Prostate cancer (PCa) is a prevalent and often aggressive malignancy. While ribosome production is a critical process in numerous cancers, the role of ribosome biogenesis-related genes (RB-RGs) in PCa remains underexplored. Therefore, this study aims to examine the expression characteristics of RB-RGs as potential prognostic markers in PCa.

Methods

Transcriptomic data were obtained from public databases to pinpoint differentially expressed genes (DEGs) associated with PCa. Among these, DEGs that were also identified as regulatory genes were selected as candidate genes and subjected to regression analysis to determine those with prognostic significance. A prognostic risk model was then created and subjected to validation. A standalone prognostic evaluation was perf

SUBMITTER: Xie J 

PROVIDER: S-EPMC12717746 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature