Glucagon-Like Peptide-2 (GLP-2) Analogues in Patients With Short Bowel Syndrome Dependent on Parenteral Support: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

ABSTRACT:

Background and objective

Short bowel syndrome (SBS) is a malabsorptive condition often requiring long-term parenteral support (PS), which is associated with significant complications. Glucagon-like peptide-2 (GLP-2) analogues are shown to enhance intestinal adaptation and reduce PS dependency. This systematic review and meta-analysis aimed to evaluate the efficacy and safety of GLP-2 analogues in adult patients with SBS dependent on PS.

Methods

A systematic search of CENTRAL, PubMed, Embase, ClinicalTrials.gov, and Google Scholar was conducted from inception till May 2025. We included randomized controlled trials (RCTs) comparing GLP-2 analogues with placebo in adult SBS patients on stable PS. We analyzed the outcomes using RevMan 5.4, with risk ratio (RR) and mean differenc

SUBMITTER: Hyder A 

PROVIDER: S-EPMC12717787 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature