Cytotoxicity Modulated by Cyanotoxins in Neuroblastoma SH-SY5Y Cells.

ABSTRACT: Aquatic prokaryotic cyanobacteria (algal blooms) produce cyanotoxins (CTs), significant pollutants in aquatic ecosystems. Direct exposure to high-concentration CTs through inhalation, skin contact, or ingestion of contaminated water can lead to hepatotoxicity and neurotoxicity. However, the effect of exposure to CTs at low concentrations remains unclear. Given that CTs can cross the blood-brain barrier via organic anion transporting polypeptides (OATPs), we investigated the effect of acute exposure to low concentrations (10 nM and 50 nM) of CTs, namely microcystin-LR (MC-LR), nodularin (NOD), cylindrospermopsin (CYN), and known neurotoxin β-N-methylamino-l-alanine (BMAA) in neuroblastoma SH-SY5Y cells. Using MTT assays, we found that all tested CTs increased cell survival at low concentrat

SUBMITTER: Niture S 

PROVIDER: S-EPMC12717869 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature