The Evolutionary Dynamics of Genetic Mutational Load Throughout Tomato Domestication History.

ABSTRACT: Understanding the impact of domestication on deleterious mutations has fascinated evolutionary biologists and breeders alike. A 'cost of domestication' has been reported for some organisms through accumulation of gene disruptions or radical amino acid changes. However, recent evidence paints a more complex picture of this phenomenon in different domesticated species. In this study, we used genomic sequences of 253 tomato accessions to investigate the evolution of deleterious mutations and genomic structural variants (SVs) through tomato domestication history. We apply phylogeny-based methods to identify deleterious mutations in the domesticated tomato as well as its semi-wild and wild relatives. Our results implicate a downward trend throughout domestication in the number of genetic varian

SUBMITTER: Razifard H 

PROVIDER: S-EPMC12717970 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature