The Common Cold Is Associated With Protection From SARS-CoV-2 Infections.

ABSTRACT:

Background

Adults and children often respond differently to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, with adults facing a higher risk of symptomatic and severe illness. We hypothesize that children's protection from symptomatic SARS-CoV-2 may be due to more frequent respiratory viral infections, which prime their airway antiviral defenses.

Methods

Using case-cohort and case-control analyses in the Human Epidemiology and Response to SARS-CoV-2 cohort, we evaluated whether infection with common respiratory viruses protects against SARS-CoV-2 infections and investigated airway molecular mechanisms by which this protection is achieved. We tested 10 493 longitudinal nasal swabs from 1156 participants for 21 respiratory pathogens. We performed RNA se

SUBMITTER: Moore CM 

PROVIDER: S-EPMC12718006 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature