Mitochondrial DNA Haplogroups, Biomarkers of Inflammation and Immune Activation, and Risk of Diabetes in Veterans With and Without Human Immunodeficiency Virus.

ABSTRACT:

Background

Type 2 diabetes mellitus (DM) is common among people with human immunodeficiency virus (HIV). We previously reported that DM risk was greater in women of African ancestry with HIV who had mitochondrial DNA (mtDNA) haplogroup L3. We examined haplogroup associations with DM and selected soluble and cellular immune biomarkers among people with HIV (PWH) and those without HIV in the Veterans Aging Cohort Study (VACS) Biomarker Cohort.

Methods

VACS participants had mtDNA haplogroups determined from genome-wide genotyping and adjudicated DM outcomes. Serum interleukin 6, D-dimer, and soluble CD14 were quantified, and cellular phenotyping was performed by flow cytometry, on blood collected during 2005-2007. Analyses included logistic and Cox regression of prevalent and i

SUBMITTER: Yan A 

PROVIDER: S-EPMC12718025 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature