Timing-dependent synergies between noninvasive motor cortex and spinal cord stimulation in chronic cervical spinal cord injury.

ABSTRACT:

Objective

Spinal cord sensory networks strongly interact with descending motor circuits. We targeted this interaction by pairing motor cortex stimulation with coordinated cervical spinal cord stimulation. Using separate non-invasive and epidural experiments, we tested the hypothesis that the strongest muscle response would occur when paired brain and spinal cord stimuli simultaneously converge within the spinal cord.

Methods

For non-invasive experiments, we measured motor evoked potentials in response to transcranial magnetic stimulation (TMS) and transcutaneous spinal cord stimulation (TSCS). We compared this noninvasive approach to intraoperative paired stimulation experiments using dorsal epidural electrodes in individuals undergoing surgery for cervical myelopathy.

Re

SUBMITTER: Murray LM 

PROVIDER: S-EPMC12718122 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature