Valvular Heart Disease Interventional Trials From 2000 to 2024: A Systematic Review.

ABSTRACT:

Background

Valvular heart disease (VHD) is a growing contributor to global cardiovascular morbidity, especially in aging populations. As transcatheter therapies expand, assessing enrollment trends and demographic representation is essential for equitable, generalizable evidence.

Objectives

The purpose of this study was to evaluate temporal trends in trial characteristics and demographic representation, particularly age and sex, in VHD interventional trials from 2000 to 2024.

Methods

We conducted a systematic review on VHD intervention trials indexed in PubMed between 2000 and 2024. Trials involving percutaneous or surgical interventions across aortic, mitral, tricuspid, and pulmonic valves were included. Descriptive and nonparametric statistics were used to assess tre

SUBMITTER: Rivera FB 

PROVIDER: S-EPMC12718138 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature