A model, mixed-species urinary catheter biofilm derived from spinal cord injury patients.

ABSTRACT: Complex multispecies biofilms consistently colonise urinary catheters, causing persistent asymptomatic bacteriuria and frequent symptomatic episodes in long-term catheterized individuals. Simple single-species models often fail to capture the complexities of mixed-species interactions and lab-based organisms may not reflect the genomic diversity found in real-world infections. Additionally, growth under flow conditions promotes robust, complex-biofilm structures. Therefore, to reflect the dynamics of in vivo infections, biofilm samples from clinical indwelling catheters of spinal cord injury (SCI) participants colonised by 5-10 species were used to establish polymicrobial macro-fluidic models, in catheters. This resulted in final models of 2-4 species biofilms. Metagenomic technique

SUBMITTER: Noorian P 

PROVIDER: S-EPMC12718157 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature