Comparative Efficacy and Safety of Minimally Invasive, Full-Endoscopic, and Biportal Transforaminal Lumbar Interbody Fusion for Lumbar Degenerative Diseases: A Network Meta-Analysis.

ABSTRACT: Study DesignNetwork Meta-analysis.ObjectiveTo evaluate the clinical efficacy and safety of minimally invasive (MIS-), full endoscopic (FE-), and biportal endoscopic (BE-) transforaminal lumbar interbody fusion (TLIF).MethodsPubMed, Embase, Cochrane Library, and ClinicalTrials.gov registry were searched up to August 2025. Randomized controlled trials and nonrandomized studies of intervention comparing MIS-TLIF, FE-TLIF, and BE-TLIF for lumbar degenerative diseases were included. Network meta-analysis was conducted using the frequentist framework, with meta-regressions assessing effect modifiers.Results49 studies (4188 patients) were included. FE-TLIF and BE-TLIF significantly reduced back pain vs MIS-TLIF from 1 month postoperatively through final follow-up. However, leg pain showed no sign

SUBMITTER: Cheng HY 

PROVIDER: S-EPMC12718175 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature