The dysregulation score method identifies epigenetic regulator genes that predict cancer prognosis and efficiency of cancer immunotherapy.

ABSTRACT: Epigenetic mechanisms play a crucial role in gene expression regulation during the initiation and progression of cancer. Despite this, over 600 epigenetic regulator (ER) genes, which are responsible for the reading, writing, and erasing of histone and DNA modifications, remain insufficiently characterized in the context of human cancer. In this study, we identified 272 cancer-specific ER genes that were dysregulated in cancer, as determined using a proposed dysregulation score method, based on analysis of over 19,000 paired tumor-normal human samples. Four novel dysregulated ER genes (DEGs), uniquely identified through this method, were shown to have roles in cell proliferation and invasion in melanoma cells. We proposed that loss-of-functional mutations within epigenetic domains may influ

SUBMITTER: Lyu J 

PROVIDER: S-EPMC12718196 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature