New Fluorescent Synthetic Retinoids as Potential RAR Agonists with Anticancer, Molecular Docking and ADME Assessments.

ABSTRACT: Natural and synthetic retinoids are derivatives of vitamin A that mediate different transcriptional activities. Synthesis of fluorescent probes can be a useful tool in cellular imaging and understanding different regulatory signaling pathways. In this study, new fluorescent synthetic retinoid analogues (3a, 3b, 4a, and 4b) were prepared and biologically screened against six different cancer and normal cell lines for assessment of their anticancer and fluorescent activities. A combination of biological assays, such as MTT, flow cytometry, gene and protein expression analysis, DNA fragmentation, and ATPase activity assays, as well as in-silico and ADME studies, was performed. All new compounds showed anti-proliferative activity (2.09-132.70 µM) against different cancer cell types with minima

SUBMITTER: Ibrahim E 

PROVIDER: S-EPMC12718261 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature