Does hypoxemia aggravate sepsis-associated acute kidney injury? Integrated clinical and experimental evidence.

ABSTRACT:

Background

Sepsis-associated acute kidney injury (SA-AKI) is a common and severe complication in critically ill patients, but the association between hypoxemia and renal dysfunction remains uncertain.

Method

We retrospectively analyzed 2292 patients with SA-AKI from the MIMIC-IV database and stratified them into four groups based on their highest arterial partial pressure of oxygen (PO₂) within 24 h of admission: < 60 mmHg, ≥ 60 to < 80 mmHg, ≥ 80 to  < 100 mmHg, and ≥ 100 mmHg. Associations between PO₂ and renal injury markers (serum creatinine [SCr] and blood urea nitrogen [BUN]) were evaluated using multivariable regression analyses, and survival outcomes were compared with Kaplan-Meier methods. To explore mechanistic pathways, a murine model was established with four exp

SUBMITTER: Mao H 

PROVIDER: S-EPMC12718267 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature