SEOH, a novel marine-derived spirostenoid: potent broad-spectrum antimicrobial activity against multidrug-resistant aquaculture pathogens.

ABSTRACT: The escalating challenge of antibiotic resistance in aquaculture critically threatens global fish health and food security, underscoring an urgent need for novel antimicrobial strategies. This study explored the bioactive potential of metabolites from the marine actinomycete Streptomyces zaomyceticus, isolated from a deep-sea sediment sample off Sharm El-Sheikh, Egypt. Bioactivity-guided fractionation led to the isolation and structural elucidation of SPIROST-8-EN-11-ONE, 3-HYDROXY- (SEOH), identified as a novel spirostenoid. SEOH exhibited significant broad-spectrum in vitro growth inhibition against a diverse panel of aquaculture-relevant pathogens, including Gram-positive and Gram-negative bacteria, and opportunistic fungi. It demonstrated potent minimum inhibitory concentrations (MICs)

SUBMITTER: Abdelaziz R 

PROVIDER: S-EPMC12718269 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature