Silver nitrate functionalized rice husk-derived graphene oxide as a nanocarrier for pH-responsive drug delivery.

ABSTRACT: In this study, graphene oxide (GO) derived from rice husk was functionalized with silver nitrate (AgNO₃) through a chemical co-precipitation method, and its biomedical applications were systematically investigated. Drug release experiments revealed a pH-responsive profile, where at pH 4.0 the cumulative release reached 32.6 ± 1.6% after 24 h, compared to 12.4 ± 1.8% at pH 7.4, highlighting its potential for targeted delivery to cancer cells. Reactive oxygen species (ROS) analysis and flow cytometry demonstrated that RH-GO/AgNO₃ treatment elevated oxidative stress and triggered apoptosis in HeLa cells. Furthermore, 5-fluorouracil (FU) was successfully loaded onto the nanocomposite surface via non-covalent interactions. Cytotoxicity assessment by MTT assay showed that F

SUBMITTER: Garwal K 

PROVIDER: S-EPMC12718294 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature