Mapping epileptogenic brain using a unified spatial-temporal-spectral source imaging framework.

ABSTRACT: Noninvasive electrophysiological source imaging (ESI) is a valuable tool for localizing and imaging brain activity, with significant potential to aid presurgical planning in focal drug-resistant epilepsy (fDRE) patients. Scalp electroencephalography (EEG) biomarkers, including interictal spikes, high-frequency oscillations (HFOs), and seizures, each offer unique capabilities in estimating the epileptogenic zone (EZ). However, there is a limited quantitative understanding of how these biomarkers differ in source-imaging precision, requiring distinct processing pipelines. Here, we developed a spatial-temporal-spectral imaging (STSI) framework for precision source imaging, and quantitatively evaluated various epilepsy biomarkers for source imaging in 2,081 individual events (spikes, HFOs, and

SUBMITTER: Jiang X 

PROVIDER: S-EPMC12718345 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature