Sleep spindle density and morphology are resilient to post-traumatic gray matter volume loss.

ABSTRACT: Moderate to severe traumatic brain injury (TBI) leads to gray matter volume (GMV) loss, cognitive dysfunction, and persistent sleep-wake complaints. Given the link between GMV and sleep spindles in healthy adults and the role of spindles in neural plasticity and protecting sleep against disturbances, we investigated GMV-spindle associations following TBI. In this cross-sectional study, 27 adults with chronic moderate to severe TBI (32.0 ± 12.2 years old) and 32 healthy controls (29.2 ± 11.5 years old) underwent full-night polysomnography and 3-Tesla MRI. Spindle density, amplitude, frequency, duration, and sigma spectral power (11-16 Hz) were computed. We tested GMV-spindle associations in 1) clusters with GMV loss following TBI (right and left frontotemporal and left temporal) and 2) regi

SUBMITTER: Kalantari N 

PROVIDER: S-EPMC12718450 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature