A systematic review of the role of methylase genes in antibiotic resistance: co-existence with extended spectrum β-lactamase and carbapenemase genes in <i>Klebsiella pneumoniae</i>.

ABSTRACT:

Background

Antibiotic resistance in multidrug-resistant Klebsiella pneumoniae (MDR-KP), particularly against carbapenems and colistin, is a critical concern, increasing morbidity and mortality among hospitalized patients. This systematic review aims to identify methylase genes in K. pneumoniae and examine their co-existence with β-lactamase and carbapenemase genes contributing to antibiotic resistance.

Methods

A literature search was conducted across three electronic databases from inception until 6 December 2023. The quality assessment followed Critical Appraisal Skills Programme (CASP) criteria. Studies focusing on methylase genes and antibiotic resistance in K. pneumoniae were included. Two authors independently screened titles, abstracts, and full te

SUBMITTER: Shahimi NH 

PROVIDER: S-EPMC12718525 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature