Multicountry surveillance study of acute febrile disease of unknown cause in sub-Saharan Africa.

ABSTRACT:

Background

Acute Febrile Disease of Unknown Cause (AFDUC) remains a major diagnostic and clinical challenge in sub-Saharan Africa (SSA), where malaria dominates while other aetiologies are under-recognised. The African Network for Improved Diagnostics, Epidemiology and Management of common Infectious Agents aimed to enhance understanding of the epidemiology of AFDUC in SSA through clinical and laboratory-based surveillance.

Methods

A multicentre prospective sentinel surveillance case-control study was conducted across urban and rural sites in Côte d'Ivoire (CI), Burkina Faso (BF) and South Africa (SA). We enrolled 6100 AFDUC cases and 1455 healthy controls between 2018 and 2022 across all study sites. Standardised clinical, laboratory and follow-up data were collected. Diagn

SUBMITTER: Belarbi E 

PROVIDER: S-EPMC12718566 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature