Associations of physical frailty, depression and their interaction with incident all-cause dementia among older adults: evidence from three prospective cohorts.

ABSTRACT:

Background

Physical frailty and depression may share common pathophysiological pathways associated with dementia and thus interact with each other. However, previous studies have primarily focused on the individual impact of these factors on dementia.

Aims

To examine the joint effect and interaction of physical frailty and depression on the risk of all-cause dementia.

Methods

We conducted prospective analyses among participants aged ≥60 years from three cohorts: the UK Biobank (UKB), the English Longitudinal Study of Ageing (ELSA) and the Health and Retirement Study (HRS). Physical frailty was assessed using modified versions of the Fried frailty phenotype. Depression was evaluated through mental health questionnaires or combined with hospital admission records. The p

SUBMITTER: Ding Y 

PROVIDER: S-EPMC12718578 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature