Opportunistic screening for osteoporosis and vertebral fracture using CT attenuation from 18F-fluorocholine PET/CT in patients with prostate cancer.

ABSTRACT:

Objective

Androgen deprivation therapy (ADT) for prostate cancer (PCa) induces bone loss and increases fracture risk, yet baseline bone mineral density (BMD) assessment is rarely performed. Opportunistic BMD evaluation using routine imaging could improve osteoporosis screening in this population. We aimed to assess the feasibility of using trabecular attenuation (TA) in Hounsfield units (HU) from the low-dose CT component of 18F-fluorocholine (FCh) positron emission tomography (PET)/CT for opportunistic osteoporosis and vertebral fracture screening in men with PCa, compared with stand-alone diagnostic CT.

Methods

In this retrospective single-centre study, 81 patients with PCa who underwent both FCh-PET/CT and stand-alone CT within 6 months were included. TA(HU) was measured

SUBMITTER: Dauchez A 

PROVIDER: S-EPMC12718580 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature