Integrating C-reactive protein flare and early MRI dynamics for enhanced prediction of immunotherapy response.

ABSTRACT:

Background

The C-reactive protein (CRP) flare response, an indicator of early immune activation, has emerged as a promising and cost-effective biomarker for predicting response to immune checkpoint inhibitors (ICIs) across various tumor types. This study evaluates the utility of CRP dynamics as a tumor-agnostic biomarker and integrates systemic inflammatory markers with advanced multiparametric MRI metrics to uncover the biological mechanisms underlying the CRP flare phenomenon and its relationship with treatment response.

Methods

Patients were stratified into three groups based on CRP kinetics: (1) flare-responders, characterized by an initial doubling of baseline CRP followed by a decrease below baseline; (2) CRP responders, defined as patients with no flare increase but a

SUBMITTER: Navarro-Garcia D 

PROVIDER: S-EPMC12718596 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature