Interventions for maintenance of surgically induced remission in Crohn's disease: a systematic review and network meta-analysis.

ABSTRACT:

Objectives

Approximately 50% of patients with Crohn's disease (CD) undergo surgery, and a significant proportion suffer from a post-surgical recurrence. We conducted a network meta-analysis to compare the efficacy of various interventions.

Design

Systematic review and network meta-analysis.

Data sources

MEDLINE, EMBASE and Cochrane Library were searched from inception up to February 2025.

Eligibility criteria

Randomised controlled trials (RCTs), reported in any language, comparing treatments used for maintaining surgically induced remission in CD were included. The primary outcomes were clinical relapse, endoscopic relapse and withdrawal due to adverse events.

Data extraction and synthesis

Two reviewers independently extracted data and assessed risk of b

SUBMITTER: Gordon M 

PROVIDER: S-EPMC12718597 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature