Autologous profiling reveals inter-patient heterogeneity in Vδ2⁺γδTIL responses to glioblastoma driven by extracellular matrix-BTN3A axis.

ABSTRACT:

Background

The effectiveness of immunotherapies against glioblastoma (GB) remains limited. A major obstacle in advancing new strategies is the reliance on non-autologous systems, which do not accurately mimic the true extent of inter-patient heterogeneity in both immune responses and tumor susceptibility. This often leads to misleading conclusions about therapeutic efficacy and targetability.

Methods

In this study, we addressed this critical gap by employing a fully autologous model. We phenotypically characterized primary αβ and γδT cells from the peripheral blood and tumors of 40 brain tumor patients, including 36 with confirmed GB, and expanded and functionally assessed the autologous anti-GB reactivity in a subset of patients.

Results

Notably, only Vδ2⁺

SUBMITTER: Nicolasen MJT 

PROVIDER: S-EPMC12718601 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature