Arrhythmic genotypes in dilated cardiomyopathy and risk of advanced heart failure.

ABSTRACT:

Background and aims

Certain genetic forms of dilated cardiomyopathy (DCM) entail a higher arrhythmic risk. It is unknown whether DCM patients with high-risk arrhythmic genotypes also develop more advanced heart failure (AHF) complications. AHF events were studied according to DCM genotype.

Methods

Clinical data from 1203 genotyped DCM patients were collected from 19 Spanish centres. Patients were classified into high-risk arrhythmic genotypes (LMNA, FLNC, desmosomal genes, PLN, TMEM43, RBM20), TTN, other genes, and genotype negative (Gen-). The primary endpoint was a composite of AHF events (ventricular assist device implantation, heart transplant, and AHF-related mortality). The secondary endpoint was a combination of malignant ventricular arrhythmias (MVA).

Results

SUBMITTER: Mora-Ayestaran N 

PROVIDER: S-EPMC12718688 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature