Air pollution causes abnormal alanine aminotransferase levels in patients with chronic hepatitis B.

ABSTRACT:

Background

To investigate the association between air pollution and abnormal alanine aminotransferase levels in patients with chronic hepatitis B treated with nucleotide/nucleoside analogs (NAs).

Methods

This cross-sectional study enrolled 1275 patients with chronic hepatitis B treated with nucleotide/NAs from 2019 to 2022 in Kaohsiung and analyzed the incidence and risk factors for abnormal alanine aminotransferase levels. Daily air pollutant concentrations were estimated for the year before enrollment.

Results

Abnormal alanine aminotransferase levels were observed in 1127 patients (88.4%) before treatment with nucleotide/NAs. Logistic regression analysis revealed that the strongest factor associated with abnormal alanine aminotransferase levels was the level of hepa

SUBMITTER: Jang TY 

PROVIDER: S-EPMC12718713 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature