Sex-specific circRNA-miRNA-mRNA networks in peripheral blood mononuclear cells of patients with idiopathic pulmonary arterial hypertension: a pilot study.

ABSTRACT:

Background

Idiopathic pulmonary artery hypertension (IPAH) is a life-threatening condition with obvious sex differences. Recently, the interactions among circRNAs, miRNAs, and mRNAs were found to be significant parts in IPAH. Thus, we want to explore whether RNA networks exist in IPAH via sex differential analyses.

Methods and materials

Illumina HiSeq was used to detect differentially expressed (DE) RNAs in peripheral blood mononuclear cells (PBMCs) from six (three male) IPAH patients. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were employed for the exhibition of differential expression levels of circRNAs, miRNAs, and mRNAs. The competing endogenous RNA (ceRNA) networks among circRNAs, miRNAs, and mRNAs were constructed on the basi

SUBMITTER: Li Y 

PROVIDER: S-EPMC12718719 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature