Causal relationships between air pollutants and upper respiratory tract infections: A two-sample, Mendelian randomization study.

ABSTRACT:

Background

The issue of air pollution is a concern that affects the health of individuals globally. Air pollutants (APs) have been linked to upper respiratory tract infections (URTIs); however, the exact association between them remains unclear.

Methods

Two-sample Mendelian randomization (MR) was performed to examine the causal relationship between APs and URTIs. Data regarding APs and URTIs were obtained from genome-wide association studies. Single-nucleotide polymorphisms associated with each exposure were defined as instrumental variables. Inverse variance weighting is the primary method for analyzing causal effects. Quality control was performed using MR-Egger, weighted mode, simple mode, and weighted median. Heterogeneity was assessed using Cochran's Q. The MR-Egger tes

SUBMITTER: Chen F 

PROVIDER: S-EPMC12718758 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature