Gpr101 expression during early stages of murine development.

ABSTRACT: The orphan G protein coupled receptor GPR101, which is implicated in X-linked acrogigantism (X-LAG), a rare pituitary disorder characterized by rapid growth a few years after birth, has received significant attention for its expression pattern in adult vertebrate tissues. However, the characterization of GPR101 expression during early embryonic development is poorly characterized. In this study, we investigated the spatiotemporal expression patterns of Gpr101 during early embryonic mouse development (E7.5-E15.5) using a global Gpr101 knock-in mouse model with an inserted LacZ reporter, Gpr101^{tm1b(KOMP)Mbp}. Similar to previously published studies using adult tissues, we found that LacZ reporter expression was largely restricted to regions of the central nervous system. Expression

SUBMITTER: Wells JR 

PROVIDER: S-EPMC12718811 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature