The alteration of fecal microbial and metabolic profile of gallstone patients in Taiwan: Single-center study.

ABSTRACT:

Background

Gallstone disease is a common health problem worldwide. The role of the gut microbiota in gallstone pathogenesis remains obscure. Our aim was to evaluate the association and crosstalk between gut microbiota, gut metabolomic, and metabolic parameters in cholesterol gallstone patients, pigmented gallstone patients, and controls.

Methods

We collected stool samples from healthy individuals and patients with gallstones in our hospital from March 2019 to February 2021. 16s rRNA sequencing was performed, followed by differential abundance analyses. Measurement of bile acids and short-chain fatty acids was conducted via targeted metabolomics.

Result

Thirty healthy individuals and 20 gallstone patients were recruited. The intergroup difference of microbial compositi

SUBMITTER: Chang TE 

PROVIDER: S-EPMC12718899 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature