Circulating T-lymphocyte subsets as promising biomarkers for the identification of sepsis-induced acute kidney injury.

ABSTRACT:

Background

This retrospective study investigated whether disturbances in circulating T-lymphocyte subsets could predict the incidence of acute kidney injury (AKI) and in-hospital mortality in patients with sepsis.

Methods

Clinical data from patients with sepsis admitted to the intensive care unit were reviewed. Logistic regression analyses were used to identify independent predictors of in-hospital mortality and the development of AKI.

Results

Of 81 patients with sepsis, 50 developed AKI. Both nonsurvivors and patients with septic AKI exhibited higher Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation (APACHE) II scores. Nonsurvivors exhibited more organ damage, with significantly lower levels of peripheral T-lymphocyte subse

SUBMITTER: Guo XL 

PROVIDER: S-EPMC12718980 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature