Exploring the diagnostic and prognostic significance of circulating tumor cells in stage II-IV colorectal cancer using a nano-based detection method.

ABSTRACT:

Background

Colorectal cancer (CRC) is a leading cause of cancer mortality globally, underscoring the urgency for a noninvasive and effective biomarker to enhance patient prognosis. Circulating tumor cells (CTCs), a potential marker for real-time tumor monitoring, are limited in clinical utility due to the low sensitivity of existing detection methods. Previously, we introduced a novel nano-based CTCs detection method that relies on the electrical properties of cell surfaces, thus eliminating the need for specific molecular biomarkers. In this study, we used this technique to evaluate the diagnostic and prognostic value of CTCs in stage II-IV CRC.

Methods

A total of 194 participants were included, consisting of 136 CRC patients and 58 healthy individuals. The peripheral blood

SUBMITTER: Liu G 

PROVIDER: S-EPMC12718985 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature