Challenges in Evaluation and Management in Tumor-Induced Osteomalacia: A Retrospective Institutional and Literature-Based Scoping Review in Korean Patients.

ABSTRACT:

Background

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by hypophosphatemia and osteomalacia, resulting from excessive production of fibroblast growth factor 23 by mesenchymal tumors. Although various imaging techniques are used to localize the tumor, the rarity of the disease poses significant challenges in tumor detection.

Methods

After retrospectively analyzing 25 TIO patients who visited the Severance bone and mineral clinic between 2004 and 2024, we added all reported TIO cases in Korea by searching PubMed, Embase, and Web of Science. Using the PRISMA method, an additional 14 reports comprising 22 patients were included.

Results

Among the 47 patients, 25 (53.2%) were male, with a median age of 52 years. Tumors were most commonl

SUBMITTER: Park S 

PROVIDER: S-EPMC12719003 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature