CSF3R Mutations Imply Adverse Prognostic Impact in Adult Acute Myeloid Leukemia Patients: A Single-Center Retrospective Study.

ABSTRACT:

Background

Activating colony-stimulating factor 3 receptor (CSF3R) mutations are uncommon in acute myeloid leukemia (AML), and their prognostic significance remains unclear.

Methods

We compared clinical, treatment response, and survival data between CSF3R-mutated and CSF3R-wild-type AML patients.

Results

CSF3R-mutated cases presented a distinct molecular profile, with T618I and T640A being the most frequent variants. Common molecular aberrations included CEBPA bZip mutations (40%) and CBF fusions (23%), as well as secondary-type AML-associated mutations such as those in ASXL1, SRSF2, and EZH2. In contrast, NPM1 mutations were significantly less common in CSF3R-mutated patients (p = 0.03). Induction responses were poorer in CSF3R-mutated AML patients, with lower comple

SUBMITTER: Yang J 

PROVIDER: S-EPMC12719048 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature