Evaluation of the prehospital diagnostic accuracy of a novel point-of-care test for NT-proBNP, D-dimer and H-FABP and large-vessel occlusion risk assessment (LVOCheck-EVA): a protocol for a multicenter prospective observational study in patients suspected of having a stroke.

ABSTRACT:

Introduction

Acute ischemic stroke (AIS) is a leading cause of permanent disability in adults and one of the most time-sensitive emergencies in modern medicine. Rapid diagnosis and initiation of thrombolytic therapy, as well as immediate access to mechanical thrombectomy for patients with large-vessel occlusion (LVO), are critical determinants of favorable outcomes. While Mobile Stroke Units (MSUs) - ambulances equipped with computed tomography (CT) imaging - have demonstrated efficacy in improving outcomes, their deployment is often constrained to urban environments due to cost-efficiency considerations. Blood biomarkers offer a potentially cost-effective alternative for stroke diagnosis and subtyping. Especially for patients with LVO, a prehospital biomarker-based identification

SUBMITTER: Rohrs K 

PROVIDER: S-EPMC12719076 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature