Metabolic inflammation, brain age and cognitive functioning in short- and long-term clinical weight loss trials.

ABSTRACT:

Background

Observational studies suggest that metabolic inflammation in obesity can impair brain health, but studies on beneficial effects of weight loss-induced improvements in such markers on brain health and their consequences for clinical outcomes are scarce.

Methods

Consequently, we investigated 53 obese participants in a short-term dietary weight loss trial (up to 4 months, 137 samples; "Muscle Metabolism Study" or "MMS") and 30 in an independent long-term trial (up to 39 months, 100 samples; "Maintain"). For each participant and visit, brain health was characterised in terms of the "brain-predicted age difference" ("brain-PAD"; the difference of the age of a person predicted with machine learning from structural brain MRI minus their chronological age). Increasingly p

SUBMITTER: Maurer L 

PROVIDER: S-EPMC12719091 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature