Circular RNA circAHSA1 serves as a stable serum biomarker for the diagnosis and progression of gastric cancer.

ABSTRACT:

Background

Gastric cancer (GC) remains a major cause of cancer-related mortality globally, largely due to the absence of reliable non-invasive biomarkers for early detection. Circular RNAs (circRNAs), characterized by covalently closed-loop structures, stability, and detectability in circulation, have emerged as promising liquid biopsy candidates.

Methods

circAHSA1 (hsa_circ_0032777) was identified through GEO dataset screening (GSE121445) and validated in GC tissues, serum, and cell lines using qRT-PCR with optimized internal reference selection. Diagnostic performance was assessed using ROC analysis and DeLong tests, evaluating circAHSA1 alone and in combination with CEA, CA199, and CA724. Biological functions were examined through proliferation, apoptosis, migration, and

SUBMITTER: He J 

PROVIDER: S-EPMC12719094 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature