Perilesional Fundus Autofluorescence Patterns Are Not Static: Longitudinal Transitions in Geographic Atrophy and Association with Disease Progression.

ABSTRACT:

Purpose

To investigate cross-sectional characteristics and longitudinal changes in perilesional fundus autofluorescence (FAF) patterns in geographic atrophy (GA).

Study design

Retrospective cohort study.

Participants

One hundred forty-three eyes from 99 patients (70 females) with foveal-sparing GA at baseline, of which 106 eyes from 76 patients were eligible for longitudinal analyses.

Methods

Best-corrected visual acuity, FAF, and OCT findings were collected at all visits. Baseline FAF patterns were determined using a 5-item classification, with tracking of longitudinal changes. Changes in GA growth rate following pattern transitions were investigated through linear mixed models.

Main outcome measures

Frequency and timing of perilesional FAF pattern tran

SUBMITTER: Antropoli A 

PROVIDER: S-EPMC12719152 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature