Intelligent responsive PVA hydrogel loaded with composite MXene nanozyme enables efficient myocardial infarction repair by disrupting the oxidative stress-inflammation cascade.

ABSTRACT: Myocardial infarction (MI) is often accompanied by irreversible cardiomyocyte damage and limited tissue regeneration, posing a persistent challenge in clinical practice. In the early phase of MI, a burst of reactive oxygen species (ROS) and the resulting pro-inflammatory feedback loop lead to disruption of the myocardial microenvironment, immune dysregulation, and ultimately, impaired repair. Therefore, early clearance of ROS, inhibition of pro-inflammatory responses, and immune modulation toward a reparative phenotype are essential for effective intervention.To address this, we developed an intelligent, stimuli-responsive polyvinyl alcohol (PVA)-based hydrogel incorporating multifunctional MXene nanozymes for the localized and controllable delivery of 4-octyl itaconate (4-OI) to infarcted

SUBMITTER: Tong J 

PROVIDER: S-EPMC12719178 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature