Enhanced magnetic thermal ablation combined with immunotherapy for hepatocellular carcinoma using engineering microspheres.

ABSTRACT: Hepatocellular carcinoma (HCC) remains a formidable challenge in oncology, characterized by high metastatic potential and recurrence rates. Traditional microwave ablation technique faces limitations due to operator dependency and potential complications. To address these challenges, we developed micron-sized polyacrylamide-iron carbonyl magnetic hyperthermia microspheres (PAM@Fe(CO)₅ MSs) for non-invasive magnetic thermal ablation (MTA). These microspheres, synthesized via the SPG membrane emulsification technique, exhibit commendable biocompatibility, size stability, and robust magnetic thermal effects. When combined with PD-1 monoclonal antibody immunotherapy, PAM@Fe(CO)₅ MSs demonstrated significant synergistic effects, leading to the markedly curtailed growth of m

SUBMITTER: Yu Z 

PROVIDER: S-EPMC12719205 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature